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Clinical Trial
. 1975 Nov 21;44(3):215-24.
doi: 10.1007/BF00428897.

Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment

D P Van Kammen, D L Murphy
Clinical Trial

Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment

D P Van Kammen et al. Psychopharmacologia. .

Abstract

Seven of nine depressed patients experienced a 4.3-fold increase in rated euphoria and activation following 30 mg d-amphetamine in a replicated dose, double blind study. d-Amphetamine was 2 to 2.3-fold more effective in producing activation, euphoria, and antidepressant effects than the same dose of l-amphetamine. Co-treatment with lithium carbonate produced a 60% (P less than 0.001) attenuation of the activation and euphoria responses to d-amphetamine. The responses to l-amphetamine were almost completely abolished by lithium. This study raises the possibility of lithium carbonate use as an adjunct in the treatment of amphetamine addiction.

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