Pathogenesis of Machupo virus infection in primates
- PMID: 182402
- PMCID: PMC2366670
Pathogenesis of Machupo virus infection in primates
Abstract
Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys.
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