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. 2008 Feb 1:2:33.
doi: 10.1186/1752-1947-2-33.

Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report

Claudia Handtrack  1 , Harald Knorr, Kerstin U Amann, Christoph Schoerner, Karl F Hilgers, Walter Geissdörfer
Affiliations

Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report

Claudia Handtrack et al. J Med Case Rep. .

Abstract

Introduction: Syphilis is well known as an infectious disease which can present with a large variety of symptoms. Clinical diagnosis can be difficult and may be complicated in modern medicine by immunosuppressive treatment and possible side effects of medication.

Case presentation: We describe a rare case of placoid chorioretinitis due to Treponema pallidum which developed after the primary symptom of proteinuria was not recognized as a rare manifestation of syphilis. Diagnosis of syphilitic chorioretinitis and/or endophthalmitis was made by broad range amplification of the bacterial 16S ribosomal RNA gene obtained from vitreous after diagnostic vitrectomy.

Conclusion: This case shows that clinicians should be alert in patients with proteinuria and chorioretinitis as they can represent rare manifestations of syphilis. Syphilis should be in the differential diagnosis of any unknown symptom and in the presumed side effects of medication.

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Figures

Figure 1
Figure 1
Findings during vitrectomy. (A) Whitish cloudy cords. (B) Retinitis with multiple ill-defined spots.
See this image and copyright information in PMC

References

    1. Tramont EC. Treponema pallidum (Syphilis) In: Mandell GL, Bennet JE, Dolin R, editor. Principles and practice of infectious diseases. sixth. Philadelphia , Elsevier; 2005. pp. 2768–2785.
    1. Peterman TA, Furness BW. The resurgence of syphilis among men who have sex with men. Curr Opin Dis. 2007;20:54–59. - PubMed
    1. Kusner DJ, Ellner JJ. Syphilis--a reversible cause of nephrotic syndrome in HIV infection. N Engl J Med. 1991;324:341–342. - PubMed
    1. Cahen R, Francois B, Trolliet P, Gilly J, Parchoux B. Aetiology of membranous glomerulonephritis: a prospective study of 82 adult patients. Nephrol Dial Transplant. 1989;4:172–180. - PubMed
    1. Krane NK, Espenan P, Walker PD, Bergman SM, Wallin JD. Renal disease and syphilis: a report of nephrotic syndrome with minimal change disease. Am J Kidney Dis. 1987;9:176–179. - PubMed

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