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Editorial
. 2008 Feb 1:5:15.
doi: 10.1186/1742-4690-5-15.

Hitting HIV where it hides

Andrew I Dayton
Editorial

Hitting HIV where it hides

Andrew I Dayton. Retrovirology. .

Abstract

The recent finding that inhibitors of PI3/Akt can sensitize HIV infected macrophages to oxidative stress-induced cell death suggest a potential new therapeutic approach to targeting HIV reservoirs.

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Figures

Figure 1
Figure 1
Proposed pathways [21] describing the effects of Tat and PI3K/Akt inhibitors on macrophage resistance to oxidative stress. Solid lines represent the flux of indicated molecular species. Dashed lines represent stimulatory (+) or inhibitory (-) regulation. Boxes enclose summaries of processes or effects.
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