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doi: 10.1016/j.cell.2008.01.005.
A notch sweeter
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- PMID: 18243091
- DOI: 10.1016/j.cell.2008.01.005
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Comment
A notch sweeter
Cell.
.
Free article
Abstract
Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.
Comment on
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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.Cell. 2008 Jan 25;132(2):247-58. doi: 10.1016/j.cell.2007.12.016. Cell. 2008. PMID: 18243100 Free PMC article.
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