Mps1 checks up on chromosome attachment
- PMID: 18243093
- DOI: 10.1016/j.cell.2008.01.008
Mps1 checks up on chromosome attachment
Abstract
The protein kinase Mps1, a crucial regulator of the spindle-assembly checkpoint, now turns out to be essential for correcting errors in chromosome attachment (Jelluma et al., 2008). Mps1 exerts this effect by regulating the activity of the Aurora B kinase through phosphorylation of its partner protein Borealin.
Comment on
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Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. Cell. 2008. PMID: 18243099
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