Comment
doi: 10.1016/j.molcel.2008.01.007.
Dubbing SAGA unveils new epigenetic crosstalk
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- PMID: 18243109
- DOI: 10.1016/j.molcel.2008.01.007
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Comment
Dubbing SAGA unveils new epigenetic crosstalk
Mol Cell.
.
Free article
Abstract
In a recent issue of Molecular Cell, two independent studies (Zhang et al., 2008; Zhao et al., 2008) provide compelling evidence that targeted deubiquitylation of histones is intimately linked to transcription activation, epigenetic regulation, and cancer progression.
Comment on
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A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.Mol Cell. 2008 Jan 18;29(1):92-101. doi: 10.1016/j.molcel.2007.12.011. Mol Cell. 2008. PMID: 18206972
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The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.Mol Cell. 2008 Jan 18;29(1):102-11. doi: 10.1016/j.molcel.2007.12.015. Mol Cell. 2008. PMID: 18206973 Free PMC article.
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