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. 2008 Apr;41(4):255-63.
doi: 10.1016/j.jcv.2007.08.021. Epub 2008 Feb 20.

Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women

Eva A Operskalski  1 , Wendy J Mack, Howard D Strickler, Audrey L French, Michael Augenbraun, Phyllis C Tien, Maria C Villacres, LaShonda Y Spencer, Marina Degiacomo, Andrea Kovacs
Affiliations

Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women

Eva A Operskalski et al. J Clin Virol. 2008 Apr.

Abstract

Background: Co-infection with hepatitis C virus (HCV) is common among HIV-infected women.

Objective: To further our understanding of the risk factors for HCV viremia and the predictors of HCV viral load among women.

Study design: We investigated sociodemographic, immunologic, and virologic factors associated with presence and level of HCV viremia among 1049 HCV-seropositive women, 882 of whom were HIV-infected and 167 HIV-uninfected at their entry into the Women's Interagency HIV Study.

Results: Plasma HCV RNA was detected in 852 (81%) of these 1049 women (range: 1.2-7.8 log(10)copies/ml). HCV-viremic women were more likely to have an HIV RNA level >100,000 copies/ml (P=0.0004), to have reported smoking (P=0.01), or to be Black (P=0.005). They were less likely to have current or resolved hepatitis B infection. HCV RNA levels were higher in women who were >35 years old, or HIV-infected. Current smoking and history of drug use (crack/freebase cocaine, marijuana, amphetamines, or heroin) were each associated with both presence and level of viremia.

Conclusions: Substance abuse counseling aimed at eliminating ongoing use of illicit drugs and tobacco may reduce clinical progression, improve response to treatment, and decrease HCV transmission by lowering levels of HCV viremia in women.

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Conflict of interest statement

Conflict of interest Authors do not have conflicts of interest in relation to the present manuscript.

References

    1. Alter MJ, Kruszon-Moran D, Nainan OV, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med. 1999;341:556–562. - PubMed
    1. Armstrong G, Wasley A, Simard EP, et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144:705–714. - PubMed
    1. Bacon MC, von Wyl V, Alden C, et al. The Women's Interagency HIV Study: an observational cohort brings clinical sciences to the bench. Clin Diagn Lab Immunol. 2005;12:1013–1019. - PMC - PubMed
    1. Baldwin GC, Tashkin DP, Buckley DM, et al. Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am J Respir Crit Care Med. 1997;156:1606–1613. - PubMed
    1. Brau N, Bini EJ, Currie S, et al. Black patients with chronic hepatitis C have a lower sustained viral response rate than non-Blacks with genotype 1, but the same with genotypes 2/3, and this is not explained by more frequent dose reductions of intervveron and ribavirin. J Viral Hepat. 2006;13:242–249. - PubMed

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