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Review
. 2008 Apr;8(2):160-5.
doi: 10.1016/j.coph.2007.12.008. Epub 2008 Feb 19.

Targeting the mitochondria to augment myocardial protection

Daniel R Schwartz  1 , Michael N Sack
Affiliations
Review

Targeting the mitochondria to augment myocardial protection

Daniel R Schwartz et al. Curr Opin Pharmacol. 2008 Apr.

Abstract

The dynamic regulation of the structure, function and turnover of mitochondria is recognized as an immutable control node maintaining cellular integrity and homeostasis. The term 'mitohormesis' has recently been coined to describe the adaptive reprogramming of mitochondrial biology in response to low levels of metabolic substrate deprivation to augment subsequent mitochondrial and cellular tolerance to biological stress. Disruption of these regulatory programs gives rise to cardiovascular and neurodegenerative diseases, and augmentation or fine-tuning of these programs may ameliorate mitochondrial and global cellular stress tolerance. This is in part via the regulation of reactive oxygen species, calcium homeostasis, and in response to caloric restriction, the capacity to augment DNA repair. The objective of this manuscript is to briefly review these regulatory programs and to postulate novel therapeutic approaches with the primary goal of modulating mitochondria to enhance tolerance to cardiac ischemic stress.

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Figures

Figure 1
Figure 1
Schematic of modulations of mitochondria to augment cardiac ischemia-tolerance
Figure 2
Figure 2
Mitochondrial directed therapeutic agents to enhance cardiac ischemia-tolerance
See this image and copyright information in PMC

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