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Case Reports
. 2008 Jan;7(1):53-4.

Primary cutaneous Cryptococcosis during therapy with methotrexate and adalimumab

Morgan L Wilson  1 , Lindsay D Sewell, Christen M Mowad
Affiliations
  • PMID: 18246698
Case Reports

Primary cutaneous Cryptococcosis during therapy with methotrexate and adalimumab

Morgan L Wilson et al. J Drugs Dermatol. 2008 Jan.

Abstract

Primary cutaneous infection with Cryptococcus neoformans is uncommon, but can occur following an inoculation injury to the skin. Tumor necrosis factor-alpha (TNF-alpha) is important in the immune response to Cryptococcus, and patients taking inhibitors of TNF-alpha may have increased susceptibility to cryptococcal infection. We report a case of primary cutaneous cryptococcosis in a patient taking adalimumab, methotrexate, and hydroxychloroquine for rheumatoid arthritis.

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