Gastric bypass surgery causes body weight loss without reducing food intake in rats
- PMID: 18247101
- DOI: 10.1007/s11695-007-9392-8
Gastric bypass surgery causes body weight loss without reducing food intake in rats
Abstract
Background: It is a common dogma that gastric bypass (GB) induces early satiety and consequent reductions in food intake and nutrient absorption. The aim of the present study was to analyze feeding behavioral and metabolic changes in rats after GB.
Methods: Male Sprague-Dawley rats at the ages of 23 and 42 weeks were placed in metabolic cages connected with a comprehensive laboratory animal monitoring system. At the age of 48 weeks they were subjected to either GB or sham operation, and then placed in metabolic cages at 51 and 62 weeks (or 3 and 14 weeks postoperatively).
Results: GB rats lost 20% of the body weight within 2-3 weeks and remained at this lower level until the end of the study at 14 weeks postoperatively. Satiety ratio was higher during daytime than nighttime in both sham-operated and GB rats, but was not significantly different between the two groups. Neither daily accumulated food intake nor food intake per 100 g of body weight was different between sham-operated and GB rats. Apparently, GB rats ate more frequently during daytime and had smaller meal size during nighttime at 3 weeks postoperatively. These changes were not present at 14 weeks postoperatively. Energy density in the feces was the same in GB and sham-operated rats postoperatively. Energy expenditure declined with age, but increased in GB rats compared with age-matched sham-operated rats.
Conclusions: GB reduced the body weight without causing early satiety, reducing food intake or inducing malabsorption. It did, however, increase energy expenditure.
Similar articles
-
Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models.PLoS One. 2013 Sep 9;8(9):e72896. doi: 10.1371/journal.pone.0072896. eCollection 2013. PLoS One. 2013. PMID: 24039816 Free PMC article.
-
Feeding behavior in rats subjected to gastrectomy or gastric bypass surgery.Eur Surg Res. 2008;40(3):279-88. doi: 10.1159/000114966. Epub 2008 Feb 5. Eur Surg Res. 2008. PMID: 18253047
-
Gastric bypass model in the obese rat to study metabolic mechanisms of weight loss.J Surg Res. 2002 Sep;107(1):56-63. doi: 10.1006/jsre.2002.6508. J Surg Res. 2002. PMID: 12384065
-
Feeding behavior and body weight development: lessons from rats subjected to gastric bypass surgery or high-fat diet.J Physiol Pharmacol. 2009 Dec;60 Suppl 7:25-31. J Physiol Pharmacol. 2009. PMID: 20388943 Review.
-
Meal patterns after bariatric surgery in mice and rats.Appetite. 2020 Mar 1;146:104340. doi: 10.1016/j.appet.2019.104340. Epub 2019 Jun 29. Appetite. 2020. PMID: 31265857 Free PMC article. Review.
Cited by
-
Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch.J Gastrointest Surg. 2010 Oct;14(10):1502-10. doi: 10.1007/s11605-010-1315-7. Epub 2010 Sep 8. J Gastrointest Surg. 2010. PMID: 20824380 Free PMC article.
-
Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models.PLoS One. 2013 Sep 9;8(9):e72896. doi: 10.1371/journal.pone.0072896. eCollection 2013. PLoS One. 2013. PMID: 24039816 Free PMC article.
-
Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats.Obesity (Silver Spring). 2009 Oct;17(10):1839-47. doi: 10.1038/oby.2009.207. Epub 2009 Jun 25. Obesity (Silver Spring). 2009. PMID: 19556976 Free PMC article.
-
Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action.Obes Surg. 2017 Jan;27(1):177-185. doi: 10.1007/s11695-016-2278-x. Obes Surg. 2017. PMID: 27576578
-
Longitudinal assessment of food intake, fecal energy loss, and energy expenditure after Roux-en-Y gastric bypass surgery in high-fat-fed obese rats.Obes Surg. 2013 Apr;23(4):531-40. doi: 10.1007/s11695-012-0846-2. Obes Surg. 2013. PMID: 23269513 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials