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. 1991 Feb;65(2):985-8.
doi: 10.1128/JVI.65.2.985-988.1991.

Sindbis virus nsP1 functions in negative-strand RNA synthesis

Y F Wang  1 , S G Sawicki, D L Sawicki
Affiliations

Sindbis virus nsP1 functions in negative-strand RNA synthesis

Y F Wang et al. J Virol. 1991 Feb.

Abstract

A mutation at nucleotide 1101 of Sindbis virus ts11 nsP1 caused temperature-sensitive negative-strand synthesis and suppressed the 24R phenotype, which is caused by a mutation in nsP4. Nonstructural proteins synthesized and accumulated by ts11 at 40 degrees C did not cause the reactivation of negative-strand synthesis upon return to 30 degrees C and did not prevent the formation of new replication complexes at 30 degrees C.

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References

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