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Comment
. 2008 Feb;7(2):99-100.
doi: 10.1016/j.cmet.2008.01.002.

More chores for TOR: de novo ceramide synthesis

Robert C Dickson  1
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Free article
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More chores for TOR: de novo ceramide synthesis

Robert C Dickson. Cell Metab. 2008 Feb.
Free article

Abstract

In this issue of Cell Metabolism, Aronova et al. (2008) show that target of rapamycin complex 2 (TORC2) controls de novo ceramide synthesis in yeast by regulating the activity of ceramide synthase. This work may provide insight into how chemotherapeutic drugs increase de novo ceramide synthesis and promote cell death in humans.

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