Review
doi: 10.1016/j.cmet.2008.01.004.
Phosphatases at the heart of FoxO metabolic control
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- PMID: 18249169
- DOI: 10.1016/j.cmet.2008.01.004
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Review
Phosphatases at the heart of FoxO metabolic control
Cell Metab.
2008 Feb.
Free article
Abstract
FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.
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