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Review
. 2008 Mar;19(2):99-103.
doi: 10.1016/j.ejim.2007.08.004. Epub 2007 Nov 7.

Multiple Endocrine Neoplasia type 1

Grzegorz Piecha  1 , Jerzy Chudek, Andrzej Wiecek
Affiliations
Review

Multiple Endocrine Neoplasia type 1

Grzegorz Piecha et al. Eur J Intern Med. 2008 Mar.

Abstract

The co-occurrence of parathyroid hyperplasia with pancreatic endocrine tumours and/or pituitary adenoma is classified as Multiple Endocrine Neoplasia type 1 (MEN-1) and is caused by a germ-line mutation in MEN-1 gene encoding a tumour suppressor protein, menin. This review presents clinical expressions, diagnosis and management of the MEN-1 syndrome. Properties and mechanisms of menin functions are also reviewed.

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