Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Mar;11(3):1724-8.
doi: 10.1128/mcb.11.3.1724-1728.1991.

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A

J M Ruppert  1 , B Vogelstein, K W Kinzler
Affiliations

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A

J M Ruppert et al. Mol Cell Biol. 1991 Mar.

Abstract

The GLI gene was previously isolated by virtue of its amplification in human glioblastomas. We have now found that GLI expression can result in the in vitro transformation of both primary and secondary rodent cells. When coexpressed with adenovirus E1A, the GLI protein functions analogously to RAS, resulting in the formation of dense foci of cells which are tumorigenic in nude mice.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. EMBO J. 1985 Jun;4(6):1609-14 - PubMed
    1. Science. 1987 Apr 3;236(4797):70-3 - PubMed
    1. Genes Dev. 1990 Jun;4(6):1053-67 - PubMed
    1. Mol Cell Biol. 1990 Oct;10(10):5408-15 - PubMed
    1. Mol Cell Biol. 1990 Feb;10(2):634-42 - PubMed

Publication types