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Review
. 2007 Dec;7(6):449-53.
doi: 10.1007/s11892-007-0076-5.

Obesity, diabetes, and chronic kidney disease

Garabed Eknoyan  1
Affiliations
Review

Obesity, diabetes, and chronic kidney disease

Garabed Eknoyan. Curr Diab Rep. 2007 Dec.

Abstract

Similar to diabetes, obesity is associated with the early onset of glomerulomegaly, hemodynamic changes of a hyperfiltering kidney, and increased albuminuria, which are potentially reversible with weight loss. However, the pathologic lesions of focal segmental glomerulosclerosis in experimental models of sustained obesity, and in obese humans presenting with massive proteinuria, are different from those of classic diabetic nephropathy. In addition, several observational, cross-sectional, and longitudinal studies document obesity as an independent risk factor for the onset, aggravated course, and poor outcomes of chronic kidney disease, even after adjustment for confounding comorbidities, including diabetes and hypertension, the two major causes of chronic kidney disease.

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