Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Apr;15(4):707-12.
doi: 10.1128/CVI.00005-08. Epub 2008 Feb 6.

Canine distemper virus strains circulating among North American dogs

Sanjay Kapil  1 , Robin W Allison, Larry Johnston 3rd, Brandy L Murray, Steven Holland, Jim Meinkoth, Bill Johnson
Affiliations

Canine distemper virus strains circulating among North American dogs

Sanjay Kapil et al. Clin Vaccine Immunol. 2008 Apr.

Abstract

Canine distemper virus (CDV) is a highly contagious virus that causes multisystemic disease in dogs. We received seven samples from dogs with CD from the United States during 2007. CDV isolates from these samples formed large, multinucleated syncytia in a Vero cell line expressing canine signaling lymphocyte activation molecule (SLAM). Based on the hemagglutinin gene sequences, the CDV isolates from three states (California, Missouri, and Oklahoma) formed two CDV genetic groups: group I (major; six of seven isolates) consisted of CDV isolates closely related to the European wildlife lineage of CDV, and group II (minor; one of seven isolates) was genetically related to the Arctic-like lineage of CDV. However, both CDV groups were genetically different from the current vaccine strains that belong to the American-1 lineage of the old (1930 to 1950) CDV isolates.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Blood film from a CDV-infected dog (OADDL 07091030). CDV inclusions (arrows) are visible within a neutrophil and a lymphocyte (aqueous Romanowsky stain; bar, 10 μm).
See this image and copyright information in PMC

References

    1. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402. - PMC - PubMed
    1. Amude, A. M., A. A. Alfieri, and A. F. Alfieri. 2006. Antemortem diagnosis of CDV infection by RT-PCR in distemper dogs with neurological deficits without the typical clinical presentation. Vet. Res. Commun. 30:679-687. - PubMed
    1. Bart, M., F. Guscetti, A. Zurbriggen, A. Pospischil, and I. Schiller. 2000. Feline infectious pneumonia: a short literature review and a retrospective immunohistological study on the involvement of Chlamydia spp. and distemper virus. Vet. J. 159:220-230. - PubMed
    1. Bolt, G., T. D. Jensen, E. Gottchalck, P. Arctander, M. J. Appel, R. Buckland, and M. Blixenkrone-Moller. 1997. Genetic diversity of the attachment (H) protein gene of current field isolates of canine distemper virus. J. Gen. Virol. 78:367-372. - PubMed
    1. Calderon, M. G., P. Remorini, O. Periolo, M. Iglesias, N. Mattion, and J. L. Torre. 2007. Detection by RT-PCR and genetic characterization of canine distemper virus from vaccinated and nonvaccinated dogs in Argentina. Vet. Microbiol. 125:341-349. - PubMed

LinkOut - more resources