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. 2008 Mar 5;130(9):2754-5.
doi: 10.1021/ja711449e. Epub 2008 Feb 8.

Palladium-catalyzed carbonylation of aryl tosylates and mesylates

Rachel H Munday  1 , Joseph R Martinelli, Stephen L Buchwald
Affiliations

Palladium-catalyzed carbonylation of aryl tosylates and mesylates

Rachel H Munday et al. J Am Chem Soc. .

Abstract

A general protocol for the palladium-catalyzed carbonylation of aryl tosylates and mesylates to form esters has been developed using a catalyst system derived from Pd(OAc)2 and the bulky, bidentate dcpp ligand. The system operates under mild conditions: atmospheric CO pressure and temperatures of 80-110 degrees C. A broad substrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heterocyclic tosylates and mesylates, and the reaction shows wide functional group tolerance.

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