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. 2008 Mar 5;130(9):2756-7.
doi: 10.1021/ja800103z. Epub 2008 Feb 8.

Nickel-catalyzed asymmetric negishi cross-couplings of secondary allylic chlorides with alkylzincs

Sunghee Son  1 , Gregory C Fu
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Nickel-catalyzed asymmetric negishi cross-couplings of secondary allylic chlorides with alkylzincs

Sunghee Son et al. J Am Chem Soc. .

Abstract

Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A1.

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