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. 2008 Mar 6;10(5):745-8.
doi: 10.1021/ol702781q. Epub 2008 Feb 8.

Catalytic asymmetric total synthesis of (+)-yohimbine

Dustin J Mergott  1 , Stephan J Zuend, Eric N Jacobsen
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Catalytic asymmetric total synthesis of (+)-yohimbine

Dustin J Mergott et al. Org Lett. .

Abstract

The total synthesis of (+)-yohimbine was achieved in 11 steps and 14% overall yield. The absolute configuration was established through a highly enantioselective thiourea-catalyzed acyl-Pictet-Spengler reaction, and the remaining 4 stereocenters were set simultaneously in a substrate-controlled intramolecular Diels-Alder reaction.

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