Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Feb;14(2):260-6.
doi: 10.3201/eid1402.061101.

Diagnosis of cystic echinococcosis, central Peruvian Highlands

Cesar M Gavidia  1 , Armando E Gonzalez, Wenbao Zhang, Donald P McManus, Luis Lopera, Berenice Ninaquispe, Hector H Garcia, Silvia Rodríguez, Manuela Verastegui, Carmen Calderon, William K Y Pan, Robert H Gilman
Affiliations

Diagnosis of cystic echinococcosis, central Peruvian Highlands

Cesar M Gavidia et al. Emerg Infect Dis. 2008 Feb.

Abstract

We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Map of the Central Peruvian Highlands.
Figure 2
Figure 2
Ultrasonographic images of cystic echinococcosis in the liver in patients from the Yanahuanca district, Central Peruvian Highlands. A) Cyst type CE1; B) Cyst type CE2; C) Cyst type CE4.
See this image and copyright information in PMC

References

    1. Moro PL, Gonzalez AE, Gilman RH. Cystic hydatid disease. In: Hunter GW, Strickland GT, Magill AJ, editors. Hunter’s tropical medicine and emerging infectious diseases. Philadelphia: W.B. Saunders; 2000. p. 866–71.
    1. Torgerson PR, Heath DD. Transmission dynamics and control options for Echinococcus granulosus. Parasitology. 2003;127(Suppl):S143–58. 10.1017/S0031182003003810 - DOI - PubMed
    1. McManus DP, Zhang W, Li J, Bartley PB. Echinococcosis. Lancet. 2003;362:1295–304. 10.1016/S0140-6736(03)14573-4 - DOI - PubMed
    1. Budke CM, Deplazes P, Torgerson PR. Global socioeconomic impact of cystic echinococcosis. Emerg Infect Dis. 2006;12:296–303. - PMC - PubMed
    1. Eckert J, Deplazes P. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin Microbiol Rev. 2004;17:107–35. 10.1128/CMR.17.1.107-135.2004 - DOI - PMC - PubMed

Publication types

MeSH terms