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. 2008 Feb 10;26(5):729-35.
doi: 10.1200/JCO.2007.14.3222.

Clinical application of the 70-gene profile: the MINDACT trial

Fatima Cardoso  1 , Laura Van't Veer, Emiel Rutgers, Sherene Loi, Stella Mook, Martine J Piccart-Gebhart
Affiliations

Clinical application of the 70-gene profile: the MINDACT trial

Fatima Cardoso et al. J Clin Oncol. .

Abstract

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

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