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Review
. 2008 May;312(1-2):71-80.
doi: 10.1007/s11010-008-9722-8. Epub 2008 Feb 8.

Chemoresistance in gliomas

Chen Lu  1 , Amal Shervington
Affiliations
Review

Chemoresistance in gliomas

Chen Lu et al. Mol Cell Biochem. 2008 May.

Abstract

Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment. This article reviews the MDR related genes, major-vault protein (MVP), anti-apoptotic protein (Bcl-2) and the molecular mechanisms that may contribute to chemoresistance, in addition to the upregulated MDR phenotypes present in CSCs that has recently been identified in gliomas. Moreover, future potential therapies that modulate MDR phenotypes and CSCs are also reviewed. An improved understanding of MDR may lead to a combined treatment, targeting both CSCs and their protective MDR phenotypes leading eventually to attractive strategies for the treatment of gliomas.

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