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Case Reports
. 2008 Feb;181(1):60-4.
doi: 10.1016/j.cancergencyto.2007.11.005.

Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor

Alireza Torabi  1 , Subodh M Lele, Dominick DiMaio, Jeffrey C Pinnt, Michelle M Hess, Marilu Nelson, Julia A Bridge
Affiliations
Case Reports

Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor

Alireza Torabi et al. Cancer Genet Cytogenet. 2008 Feb.

Abstract

Solitary fibrous tumor is a mesenchymal tumor that was initially described as a pleural-based lesion, but later was discovered in many other locations. The light-microscopic appearance of solitary fibrous tumor may overlap with other diagnostic entities; however, consistent tumor cell CD34 immunoreactivity is useful in establishing the diagnosis. Limited data suggest that solitary fibrous tumors are karyotypically diverse, and no common or characteristic anomaly has yet emerged for this entity. Cytogenetic analysis of two solitary fibrous tumors, one peritoneal and the other arising in the liver, revealed predominantly structural abnormalities in the former and numerical imbalances in the latter. Clonal karyotypic abnormalities were lacking in three additional solitary fibrous tumors.

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Figures

Figure 1
Figure 1
Representative karyotype of Case 1 illustrating the following abnormal complement: 83,XXYY,-1,-4,-6,-9,-13,-15,-17,-18,-22. Loss of one chromosome 19 homologue seen in this metaphase cell only was a random loss.
Figure 2
Figure 2
Representative karyotype of one of the abnormal sideline clones identified in Case 2 with the following nomenclature: 47,X,add(X)(q22),del(2)(q32q35),+5,add(18)(p11.2).
See this image and copyright information in PMC

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