[The importance of serological parameters in the diagnosis and therapy monitoring of osteoporosis]

Abstract

60 female patients with osteoporosis are examined to analyse several parameters of the blood serum relative to their value for diagnosis and therapeutic results. Osteocalcin seems to be a specific factor of the serum to determine formation of bone. The activity of the alkaline phosphatase as an indicator for new formation of bone and the concentration of hydroxyproline in the urine as an indicator for bone resorption are not sensitive enough, to detect slight changes in metabolic bone processes. The concentration of parathormone, calcium and phosphate in the blood serum are not suited for diagnosis and controlling the therapeutical results of osteoporosis. They are rather fit for differential diagnosis of other osteological diseases. Osteocalcin seems to be a serum parameter with relationship to radiological, clinical and laboratory findings. It may help to find the right diagnosis in the case of other osteological diseases and controlling the therapeutical effects.