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Comment
. 2008 Feb 8;132(3):337-9.
doi: 10.1016/j.cell.2008.01.023.

Clearing the path for germ cells

Holger Knaut  1 , Alexander F Schier
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Free article
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Clearing the path for germ cells

Holger Knaut et al. Cell. .
Free article

Abstract

The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.

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