Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Feb 8;132(3):339-41.
doi: 10.1016/j.cell.2008.01.022.

Secreting tumor suppression

Yuchen Chien  1 , Scott W Lowe
Affiliations
Comment

Secreting tumor suppression

Yuchen Chien et al. Cell. .

Abstract

Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1. IGFBP7 and BRAF-Induced Cellular Senescence
Early during melanoma progression, melanocytes acquire BRAF mutations that stimulate proliferation but also trigger senescence, in part, via enhanced secretion of insulin growth factor binding protein 7 (IGFBP7). Silencing of IGFBP7 enables BRAF-expressing melanocytes to escape senescence and progress toward melanoma. The resulting melanoma cells remain sensitive to the induction of apoptosis by addition of IGFBP7.
See this image and copyright information in PMC

Comment on

References

    1. Campisi J, d’Adda di Fagagna F. Nat Rev Mol Cell Biol. 2007;8:729–740. - PubMed
    1. Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K. Cancer Cell. 2006;10:459–472. - PMC - PubMed
    1. Hayflick L. Exp Cell Res. 1965;37:614–636. - PubMed
    1. Kortlever RM, Higgins PJ, Bernards R. Nat Cell Biol. 2006;8:877–884. - PMC - PubMed
    1. Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Proc Natl Acad Sci USA. 2001;98:12072–12077. - PMC - PubMed

Substances