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. 1991 Apr 19;252(5004):427-31.
doi: 10.1126/science.1826797.

Engraftment and development of human T and B cells in mice after bone marrow transplantation

I Lubin  1 , Y Faktorowich, T Lapidot, Y Gan, Z Eshhar, E Gazit, M Levite, Y Reisner
Affiliations

Engraftment and development of human T and B cells in mice after bone marrow transplantation

I Lubin et al. Science. .

Abstract

A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.

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