Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 May;31(5):1026-30.
doi: 10.2337/dc07-2102. Epub 2008 Feb 11.

Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction

E Jeffrey Metter  1 , B Gwen Windham, Marcello Maggio, Eleanor M Simonsick, Shari M Ling, Josephine M Egan, Luigi Ferrucci
Affiliations

Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction

E Jeffrey Metter et al. Diabetes Care. 2008 May.

Abstract

Objective: To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality.

Research design and methods: A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included in this study. Proportional hazards using the longitudinally collected data and Bayesian model averaging were used to examine the association of OGTT measurements individually and grouped with mortality, adjusting for covariates.

Results: Participants were followed for a median 20.3 years (range 0.5-40). The first-hour OGTT glucose and insulin levels increased only modestly with age, whereas levels during the second hour increased 4% per decade. Individually, 100- and 120-min glucose measures and fasting and 100-min insulin levels were all independent predictors of mortality. When all measures were considered together, only higher 120-min glucose was a significant independent risk factor for mortality.

Conclusion: The steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Age,date and sex-adjusted risk ratio (RR) for mortality comparing the 75th percentile versus the 25th percentile for the time-specific measurement, adjusted for insulin and glucose OGTT. The graph shows the median RR and 95 percent confidence intervals at each time point: (a) All-cause mortality, (b) Cardiovascular mortality.
See this image and copyright information in PMC

References

    1. Balkau B, Bertrais S, Ducimetiere P, Eschwege E. Is there a glycemic threshold for mortality risk? Diabetes Care. 1999;22:696–699. - PubMed
    1. Meigs JB, Muller DC, Nathan DM, Blake DR, Andres R. The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes. 2003;52:1475–1484. - PubMed
    1. Sorkin JD, Muller DC, Fleg JL, Andres R. The relation of fasting and 2-h postchallenge plasma glucose concentrations to mortality: Data from the Baltimore Longitudinal Study of Aging with a critical review of the literature. Diabetes Care. 2005;28:2626–2632. - PubMed
    1. DECODE Study Group. Glucose tolerance and mortality: comparison of WHO and American Diabetic Association diagnostic criteria. Lancet. 1999;354:617–621. - PubMed
    1. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 1992;15:318–368. - PubMed

Publication types