Testing protocols in the intensive care unit: complex trials of complex interventions for complex patients

Editorial

Jean-Daniel Chiche et al. JAMA. 2008.

. 2008 Feb 13;299(6):693-5.

doi: 10.1001/jama.299.6.693.

No abstract available

Comment in

Randomized controlled trials in critical care medicine.
Zijlstra JG, Ligtenberg JJ, Girbes AR. Zijlstra JG, et al. JAMA. 2008 Jul 2;300(1):43; author reply 43-4. doi: 10.1001/jama.300.1.43-a. JAMA. 2008. PMID: 18594038 No abstract available.

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE; Lung Open Ventilation Study Investigators. Meade MO, et al. JAMA. 2008 Feb 13;299(6):637-45. doi: 10.1001/jama.299.6.637. JAMA. 2008. PMID: 18270352 Clinical Trial.
Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L; Expiratory Pressure (Express) Study Group. Mercat A, et al. JAMA. 2008 Feb 13;299(6):646-55. doi: 10.1001/jama.299.6.646. JAMA. 2008. PMID: 18270353 Clinical Trial.
Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome.
Gattinoni L, Caironi P. Gattinoni L, et al. JAMA. 2008 Feb 13;299(6):691-3. doi: 10.1001/jama.299.6.691. JAMA. 2008. PMID: 18270359 No abstract available.