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. 2008 Mar;13(2):217-36.
doi: 10.1080/13547500701676019.

TGF-beta signalling-related markers in cancer patients with bone metastasis

Jose Baselga  1 , Mace L Rothenberg, Josep Tabernero, Joan Seoane, Thomas Daly, Ann Cleverly, Brandi Berry, Susanne K Rhoades, Chad A Ray, Jeffrey Fill, Daphne L Farrington, Lisa Anne Wallace, Jonathan M Yingling, Michael Lahn, Carlos Arteaga, Michael Carducci
Affiliations

TGF-beta signalling-related markers in cancer patients with bone metastasis

Jose Baselga et al. Biomarkers. 2008 Mar.

Abstract

We measured transforming growth factor (TGF)-beta-dependent biomarkers in plasma and in peripheral blood mononuclear cells (PBMCs) to identify suitable pharmacodynamic markers for future clinical trials with TGF-beta inhibitors. Forty-nine patients with bone metastasis were enrolled in the study, including patients with breast (n=23) and prostate cancer (n=15). Plasma TGF-beta1 levels were elevated in more than half of the cancer patients (geometric mean 2.63 ng ml(-1)) and positively correlated with increased platelet factor 4 (PF4) levels, parathyroid-related protein (PTHrP), von Willebrand Factor (vWF) and interleukin (IL)-10. PBMC were stimulated ex vivo to determine the individual biological variability of an ex vivo assay measuring pSMAD expression. This assay performed sufficiently well to allow its future use in a clinical trial of a TGF-beta inhibitor.

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