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. 2008 Apr;46(4):1514-6.
doi: 10.1128/JCM.01938-07. Epub 2008 Feb 13.

Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence

O J Strauss  1 , R M Warren, A Jordaan, E M Streicher, M Hanekom, A A Falmer, H Albert, A Trollip, E Hoosain, P D van Helden, T C Victor
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Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence

O J Strauss et al. J Clin Microbiol. 2008 Apr.

Abstract

The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations.

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