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. 2008 Apr;28(4):258-63.
doi: 10.1038/sj.jp.7211913. Epub 2008 Feb 14.

Maternal bisphenol-A levels at delivery: a looming problem?

V Padmanabhan  1 , K Siefert, S Ransom, T Johnson, J Pinkerton, L Anderson, L Tao, K Kannan
Affiliations

Maternal bisphenol-A levels at delivery: a looming problem?

V Padmanabhan et al. J Perinatol. 2008 Apr.

Abstract

Objective: The objective was to determine whether bisphenol-A (BPA) is found in maternal circulation of pregnant women in the US population and is related to gestational length and birth weight.

Method: Circulating levels of BPA were quantified by high performance liquid chromatography-tandem mass spectrometry at delivery in 40 southeastern Michigan mothers and correlated with gestational length and birth weight of offspring.

Result: Maternal levels of unconjugated BPA ranged between 0.5 and 22.3 ng ml(-1) in southeastern Michigan mothers. There was no correlation between BPA concentrations and gestational length or birth weight of offspring.

Conclusion: This is the first study to document measurable levels of BPA in maternal blood of the US population. Long-term follow-up studies of offspring are needed to validate or refute concerns over human fetal exposure to synthetic exogenous steroids.

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Figures

Fig. 1
Fig. 1
HPLC-MS/MS chromatograms showing procedural blank, BPA standard (1 ppb and 50 ppb), a serum sample spiked with BPA (20 ppb), and a maternal blood sample. Multiple reaction monitoring for the transitions of 227>212 was used to acquire BPA data.
Fig. 2
Fig. 2
Maternal levels of BPA (mean ±SEM) in Southeastern Michigan relative to age, BMI and sex of the offspring.
Fig. 3
Fig. 3
Gestational length and offspring weight (mean ±SEM) relative to maternal BPA levels of Southeastern Michigan
See this image and copyright information in PMC

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