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Comment
. 2008 Feb;28(2):143-5.
doi: 10.1016/j.immuni.2008.01.006.

The importance of prolonged binding to antigen-presenting cells for T cell fate decisions

John J Engelhardt  1 , Matthew F Krummel
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Free article
Comment

The importance of prolonged binding to antigen-presenting cells for T cell fate decisions

John J Engelhardt et al. Immunity. 2008 Feb.
Free article

Abstract

How critical is it for T cells to stably arrest on antigen-presenting cells? In this issue of Immunity, Scholer et al. (2008) demonstrate profound effector and memory defects for CD8(+) T cells encountering "nonsticky" antigen-presenting cells lacking intercellular adhesion molecule-1.

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