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Review
. 2008 Apr 11;368(3):815-9.
doi: 10.1016/j.bbrc.2008.02.008. Epub 2008 Feb 12.

A putative role for apelin in the etiology of obesity

Srujana Rayalam  1 , Mary Anne Della-Fera, Paul A Krieg, Christopher M Cox, Allan Robins, Clifton A Baile
Affiliations
Review

A putative role for apelin in the etiology of obesity

Srujana Rayalam et al. Biochem Biophys Res Commun. .

Abstract

Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

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