Focal segmental glomerulosclerosis: recent advances

Abstract

Purpose of review: Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children.

Recent findings: The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis.

Summary: A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.