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. 1991 May 24;57(3):223-7.
doi: 10.1016/0304-3835(91)90161-a.

Antiproliferative activity of retinoids, interferon alpha and their combination in five human transformed cell lines

J R Frey  1 , R Peck, W Bollag
Affiliations

Antiproliferative activity of retinoids, interferon alpha and their combination in five human transformed cell lines

J R Frey et al. Cancer Lett. .

Abstract

Tretinoin, isotretinoin and acitretin were examined for their capacity to modulate the proliferation of the cell lines: HL-60 (acute promyelocytic leukemia), MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Retinoids inhibited proliferation to a varying extent in all 5 cell lines. The cytokine IFN alpha had a significant antiproliferative effect only on HL-60, SCC4 and SCC15. The combination of retinoids with IFN alpha led in all 5 cell lines to a more profound reduction in proliferation than either retinoids or IFN alpha alone.

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