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. 2008 Mar;4(3):152-6.
doi: 10.1038/nchembio0308-152.

Expanding chemical biology of 2-oxoglutarate oxygenases

Christoph Loenarz  1 , Christopher J Schofield
Affiliations

Expanding chemical biology of 2-oxoglutarate oxygenases

Christoph Loenarz et al. Nat Chem Biol. 2008 Mar.

Abstract

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.

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