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. 2008 Mar;26(3):313-5.
doi: 10.1038/nbt1383. Epub 2008 Feb 17.

Marked differences in differentiation propensity among human embryonic stem cell lines

Kenji Osafune  1 , Leslie Caron, Malgorzata Borowiak, Rita J Martinez, Claire S Fitz-Gerald, Yasunori Sato, Chad A Cowan, Kenneth R Chien, Douglas A Melton
Affiliations

Marked differences in differentiation propensity among human embryonic stem cell lines

Kenji Osafune et al. Nat Biotechnol. 2008 Mar.

Abstract

The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific lineages, often with >100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic differentiation and HUES 3 for cardiomyocyte generation. These non-trivial differences in developmental potential among hES cell lines point to the importance of screening and deriving lines for lineage-specific differentiation.

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