Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Feb 15;22(4):411-5.
doi: 10.1101/gad.1646608.

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

Jiafeng Gu  1 , Michael R Lieber
Affiliations
Review

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

Jiafeng Gu et al. Genes Dev. .
No abstract available

PubMed Disclaimer

Comment on

References

    1. Aniukwu J., Glickman M.S., Shuman S. The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes & Dev. 2008 doi: 10.1101/gad.1631908. (this issue) - DOI - PMC - PubMed
    1. Aravind L., Koonin E.V. Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. Genome Res. 2001;11:1365–1374. - PMC - PubMed
    1. Bertocci B., De Smet A., Weill J.C., Reynaud C.A. Nonoverlapping functions of DNA polymerases μ, λ, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Immunity. 2006;25:31–41. - PubMed
    1. Brissett N.C., Pitcher R.S., Juarez R., Picher A.J., Green A.J., Dafforn T.R., Fox G.C., Blanco L., Doherty A.J. Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science. 2007;318:456–459. - PubMed
    1. Critchlow S., Bowater R., Jackson S.P. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 1997;7:588–598. - PubMed

LinkOut - more resources