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. 2008 Jun;35(6):1142-6.
doi: 10.1007/s00259-008-0734-0. Epub 2008 Feb 19.

MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data

Thomas Beyer  1 , Markus Weigert, Harald H Quick, Uwe Pietrzyk, Florian Vogt, Christoph Palm, Gerald Antoch, Stefan P Müller, Andreas Bockisch
Affiliations

MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data

Thomas Beyer et al. Eur J Nucl Med Mol Imaging. 2008 Jun.

Abstract

Purpose: MR-based attenuation correction (AC) will become an integral part of combined PET/MR systems. Here, we propose a toolbox to validate MR-AC of clinical PET/MRI data sets.

Methods: Torso scans of ten patients were acquired on a combined PET/CT and on a 1.5-T MRI system. MR-based attenuation data were derived from the CT following MR-CT image co-registration and subsequent histogram matching. PET images were reconstructed after CT- (PET(CT)) and MR-based AC (PET(MRI)). Lesion-to-background (L/B) ratios were estimated on PET(CT) and PET(MRI).

Results: MR-CT histogram matching leads to a mean voxel intensity difference in the CT- and MR-based attenuation images of 12% (max). Mean differences between PET(MRI) and PET(CT) were 19% (max). L/B ratios were similar except for the lung where local misregistration and intensity transformation leads to a biased PET(MRI).

Conclusion: Our toolbox can be used to study pitfalls in MR-AC. We found that co-registration accuracy and pixel value transformation determine the accuracy of PET(MRI).

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