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. 2008 Feb;74(3):267-72.
doi: 10.1055/s-2008-1034311. Epub 2008 Feb 18.

Isolation and characterization of new Cannabis constituents from a high potency variety

Mohamed M Radwan  1 , Samir A Ross, Desmond Slade, Safwat A Ahmed, Fazila Zulfiqar, Mahmoud A Elsohly
Affiliations

Isolation and characterization of new Cannabis constituents from a high potency variety

Mohamed M Radwan et al. Planta Med. 2008 Feb.

Abstract

Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (+/-)-6,7-trans-epoxycannabigerolic acid ( 2), (+/-)-6,7- CIS-epoxycannabigerolic acid ( 3), (+/-)-6,7- CIS-epoxycannabigerol ( 4), (+/-)-6,7-trans-epoxycannabigerol ( 5), 5'-methyl-4-pentylbiphenyl-2,2',6-triol ( 7), and 7-methoxycannabispirone ( 8), along with seven known compounds namely, cannabigerolic acid ( 1), 5'-methoxycannabigerolic acid ( 6), cannabispirone ( 9), beta-cannabispiranol ( 10), dehydrocannabifuran ( 11), cannflavin B ( 12) and cannabigerol ( 13). The antimicrobial as well as the antileishmanial activities were investigated.

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Figures

Fig. 1
Fig. 1
HMBC correlations of 2 and 3 (→) and key ROESY correlations of 3 (↔).
Fig. 2
Fig. 2
Key HMBC correlations of 6.
See this image and copyright information in PMC

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