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. 1991;312(5):197-202.

[Inhibitor effect of CD8+CD57+ lymphocytes on cell-mediated cytotoxicity: characterization of suppressor factor]

[Article in French]
B Autran  1 , B Sadat-Sowti, P Debre
Affiliations
  • PMID: 1828385

[Inhibitor effect of CD8+CD57+ lymphocytes on cell-mediated cytotoxicity: characterization of suppressor factor]

[Article in French]
B Autran et al. C R Acad Sci III. 1991.

Abstract

We report a new suppressor function of CD8+CD57+ lymphocytes from HIV-seropositive patients or allotransplanted recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha beta. A preliminary biochemical characterization indicates that the CD8+CD57+ inhibitory activity 1. is heat and trypsin resistant, 2. specifically binds to Concanavalin A suggesting its glycosylation, 3. is mediated by a 20-30 kD molecule.

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