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. 1991 Jun 3;283(2):199-202.
doi: 10.1016/0014-5793(91)80587-s.

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11

I Kawashima  1 , J Ohsumi, K Mita-Honjo, K Shimoda-Takano, H Ishikawa, S Sakakibara, K Miyadai, Y Takiguchi
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Free article

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11

I Kawashima et al. FEBS Lett. .
Free article

Abstract

A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open reading frame coding for an AGIF precursor of 199 amino acids. Analysis of the sequence of this cDNA revealed identity of this factor with a recently reported novel cytokine, designated interleukin-11 (IL-11). AGIF/IL-11 may play an important role in stromal cell-associated hematopoeisis through its regulatory action on adipocyte differentiation in the bone marrow microenvironment.

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