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. 2008 Feb 19:4:10.
doi: 10.1186/1744-9081-4-10.

Failure to detect the 22q11.2 duplication syndrome rearrangement among patients with schizophrenia

Anna Brunet  1 , Lluís Armengol, Trini Pelaez, Roser Guillamat, Vicenç Vallès, Elisabeth Gabau, Xavier Estivill, Miriam Guitart
Affiliations

Failure to detect the 22q11.2 duplication syndrome rearrangement among patients with schizophrenia

Anna Brunet et al. Behav Brain Funct. .

Abstract

Chromosome aberrations have long been studied in an effort to identify susceptibility genes for schizophrenia. Chromosome 22q11.2 microdeletion is associated with DiGeorge and Velocardiofacial syndromes (DG/VCF) and provides the most convincing evidence of an association between molecular cytogenetic abnormality and schizophrenia. In addition, this region is one of the best replicated linkage findings for schizophrenia. Recently, the reciprocal microduplication on 22q11.2 has been reported as a new syndrome. Preliminary data indicates that individuals with these duplications also suffer from neuropsychiatric disorders. In this study we have investigated the appropriateness of testing schizophrenia patients for the 22q11.2 microduplication. We used multiplex ligation-dependent probe amplification (MLPA) to measure copy number changes on the 22q11.2 region in a sample of 190 patients with schizophrenia. Our results corroborate the prevalence of the 22q11.2 microdeletion in patients with schizophrenia and clinical features of DG/VCFS and do not suggest an association between 22q11.2 microduplication and schizophrenia.

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Figures

Figure 1
Figure 1
MLPA electropherograms showing the peaks from the probes set used in the analysis of the chromosome 22q11.2 duplication syndrome. Specific probes for the chromosome 22q11.2 region (HIRA, TBX-1, COMT and ZDHHC8) are indicated with arrows. A: A 22q11.2 microdeletion trace. B: A normal sample trace. C: A 22q11.2 microduplication trace.
See this image and copyright information in PMC

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