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Review
. 2008 Jun 6;283(23):15515-9.
doi: 10.1074/jbc.R800004200. Epub 2008 Feb 19.

Nitro-fatty acid formation and signaling

Bruce A Freeman  1 , Paul R S Baker, Francisco J Schopfer, Steven R Woodcock, Alessandra Napolitano, Marco d'Ischia
Affiliations
Review

Nitro-fatty acid formation and signaling

Bruce A Freeman et al. J Biol Chem. .
No abstract available

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Figures

FIGURE 1.
FIGURE 1.
Mechanisms of fatty acid nitration and oxidation by nitric oxide-derived species.
FIGURE 2.
FIGURE 2.
Biological trafficking and actions of NO2-FA derivatives. Nitroalkenes are stable in free and/or esterified form in hydrophobic micellar, lipoprotein, or membrane environments and can serve as a reserve of NO2-FAs in free and/or esterified form. Once access to an aqueous milieu is gained, nitroalkenes can decay or possibly be metabolized to release nitric oxide (•NO), bind and activate PPARs, or elicit multiple biological responses as a consequence of electrophilic reactivity.
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References

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