Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jun 6;283(23):15521-5.
doi: 10.1074/jbc.R700049200. Epub 2008 Feb 19.

Cholesterol, reactive oxygen species, and the formation of biologically active mediators

Robert C Murphy  1 , Kyle M Johnson
Affiliations
Review

Cholesterol, reactive oxygen species, and the formation of biologically active mediators

Robert C Murphy et al. J Biol Chem. .
No abstract available

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.
Pathways of free radical oxidation of Ch by initial abstraction of a C-7 hydrogen atom and subsequent reactions of peroxy radicals. 5,6-Epoxy-Ch can be made by both radical and nonradical mechanisms. LOO• refers to a lipid hydroperoxy radical intermediate; LOH refers to a hydroxy lipid; LOOH refers to a lipid hydroperoxide; and LO• refers to a lipid alkoxyl radical intermediate.
FIGURE 2.
FIGURE 2.
Pathways of nonradical modification of Ch by singlet oxygen and ozone.
See this image and copyright information in PMC

References

    1. Koumanov, K. S., Tessier, C., Momchilova, A. B., Rainteau, D., Wolf, C., and Quinn, P. J. (2005) Arch. Biochem. Biophys. 434 150–158 - PubMed
    1. Brown, M. S., and Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96 11041–11048 - PMC - PubMed
    1. Smith, L. L. (1981) Cholesterol Autoxidation, Plenum Press, New York
    1. Vine, D. F., Croft, K. D., Beilin, L. J., and Mamo, J. C. (1997) Lipids 32 887–893 - PubMed
    1. Smith, L. L. (1987) Chem. Phys. Lipids 44 87–125 - PubMed

Publication types