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Review
. 2008 Feb 21;14(7):1137-40.
doi: 10.3748/wjg.14.1137.

Clear cell adenocarcinoma of the colon: a case report and review of literature

Koichi Soga  1 , Hideyuki Konishi, Natsuko Tatsumi, Chika Konishi, Keimei Nakano, Naoki Wakabayashi, Shoji Mitsufuji, Keisho Kataoka, Takeshi Okanoue, Ken-Ichi Mukaisho, Takanori Hattori
Affiliations
Review

Clear cell adenocarcinoma of the colon: a case report and review of literature

Koichi Soga et al. World J Gastroenterol. .

Abstract

A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors in the colon.

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Figures

Figure 1
Figure 1
The 7-mm diameter “berrylike” polyp on the sigmoid colon.
Figure 2
Figure 2
A: Polypectomy specimen containing adenoma and partial clear cell carcinoma. The cut margin was showed on the bottom side; B: There was no transition between the areas of the usual adenoma on right top of the figure and the clear cell adenocarcinoma on left bottom of the figure; C: The cut margin was showed normal colonic mucosa, indicating that this polypectomy was curative treatment. Each bar indicates 200 μm.
Figure 3
Figure 3
HE staining shows clear cell carcinoma with clear cytoplasm in a normal colonic adenoma (Two top figures). PAS staining shows purple staining on the adenoma on right of the figure, and mild purple staining on the clear cell carcinoma on left of the figure. Alcian blue staining shows granular mucin on the adenoma on right of the figure, and there are no staining on the clear cell carcinoma on left of the figure. Each bar indicates 200 μm.
Figure 4
Figure 4
Ki67 is about 70% positive, p53 is positive, CK7 is negative, CK20 is positive, and CD10 is weakly positive on immunochemical staining. Each bar indicates 200 μm.
See this image and copyright information in PMC

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