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. 2008 Jan-Feb;45(1):22-5.
doi: 10.3928/01913913-20080101-16.

The relationship between tumor cell differentiation and age at diagnosis in retinoblastoma

Jagadeesan Madhavan  1 , Anuradha Ganesh, Joseph Roy, Jyotirmay Biswas, Govindasamy Kumaramanickavel
Affiliations

The relationship between tumor cell differentiation and age at diagnosis in retinoblastoma

Jagadeesan Madhavan et al. J Pediatr Ophthalmol Strabismus. 2008 Jan-Feb.

Abstract

Purpose: To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma.

Methods: Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed.

Results: Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P < .0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors.

Conclusions: Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.

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